2022 NFL Mock Draft – Round 4
| Pick | Team | Player |
|---|---|---|
| 106. | Jacksonville Jaguars | Josh Jobe CB | Alabama |
| 107. | Houston Texans | Khalil Shakir WR | Boise State |
| 108. | Houston Texans | Brandon Smith LB | Penn State |
| 109. | Seattle Seahawks | Martin Emerson CB | Mississippi State |
| 110. | Baltimore Ravens | Cordell Volson OT | North Dakota State |
| 111. | New York Jets | Cade Otton TE | Washington |
| 112. | New York Giants | Jeremey Ruckert TE | Ohio State |
| 113. | Washington Commanders | Justin Shaffer OG | Georgia |
| 114. | Atlanta Falcons | Nick Cross S | Maryland |
| 115. | Denver Broncos | Matthew Butler DT | Tennessee |
| 116. | Denver Broncos | Brian Robinson Jr. RB | Alabama |
| 117. | New York Jets | Tyrese Robinson OG | Oklahoma |
| 118. | Cleveland Browns | Jermayne Lole DT | Arizona State |
| 119. | Baltimore Ravens | Dohnovan West OG | Arizona State |
| 120. | New Orleans Saints | John Ridgeway DT | Arkansas |
| 121. | Kansas City Chiefs | Luke Fortner OG | Kentucky |
| 122. | Indianapolis Colts | Alec Pierce WR | Cincinnati |
| 123. | Los Angeles Chargers | Myjai Sanders EDGE | Cincinnati |
| 124. | Philadelphia Eagles | Tyler Badie RB | Missouri |
| 125. | Miami Dolphins | Dameon Pierce RB | Florida |
| 126. | Las Vegas Raiders | Zyon McCollum CB | Sam Houston State |
| 127. | New England Patriots | DeAngelo Malone EDGE | Western Kentucky |
| 128. | Baltimore Ravens | Kyren Williams RB | Notre Dame |
| 129. | Dallas Cowboys | Isaiah Thomas EDGE | Oklahoma |
| 130. | Buffalo Bills | Matt Waletzko OT | North Dakota |
| 131. | Tennessee Titans | Braxton Jones OT | Southern Utah |
| 132. | Green Bay Packers | Jake Ferguson TE | Wisconsin |
| 133. | Tampa Bay Buccaneers | Zamir White RB | Georgia |
| 134. | San Francisco 49ers | Rachaad White RB | Arizona State |
| 135. | Kansas City Chiefs | Eyioma Uwazurike DT | Iowa State |
| 136. | Cincinnati Bengals | Max Mitchell OT | Lousiana |
| 137. | Carolina Panthers | Cam Jurgens OG | Nebraska |
| 138. | Pittsburgh Steelers | Montaric Brown CB | Arkansas |
| 139. | Baltimore Ravens | Jelani Woods TE | Virginia |
| 140. | Green Bay Packers | Tycen Anderson S | Toledo |
| 141. | Baltimore Ravens | Dane Belton S | Iowa |
| 142. | Los Angeles Rams | Terrel Bernard LB | Baylor |
| 143. | Tennessee Titans | Chigoziem Okonkwo TE | Maryland |
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